Non-adherent effect of the gauze coated with PNIAAm on treatment of the full-thickness skin wound in rats.

概要

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Taking advantage of the conversion from water-insoluble to water- soluble states depending on the lower critical temperature (LOST) in thermoresponsive polymer ( PNIPAAm), the author has developed new type gauze coated with PNIPAAm that allows us easily to be removed from a wound simply by pouring cold solution onto this gauze. In this study, the new type gauze was placed onto a 4×4cm of full-thickness skin wound in the rat for 4, 7, and 14 days, respectively. When cold normal saline of 4°C which is below LOST was poured onto this gauze before removal, PNIPAAm was solubilized and therefore the gauze was easily removed without incurring any tissue damage even at 14 days after covering.
一般社団法人日本人工臓器学会の論文