Clinical study on Mizoribine in patients in whom DMARDs were ineffective.

概要

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We treated twelve patients who had previously received DMARDs to no effect with Mizoribine (100mg-150mg) for one year. We then evaluated their clinical findings (Lansbury index) and laboratory data (CRP, RAHA). Mizoribine was effective in 5 patients (41%) and ineffective in 7 patients (59%). The effective group showed an improvement in their Lansbury index four months after starting the treatment (P<0.01).One patient began to feel anacatesthesia after five months and stopped the medication. One week after stopping their symptoms improved.There were no statistical differrences regarding age, morbidity year, class, stage, combination rate of PSL and Mizoribine dose between the effective and ineffective group, although the effective group had a tendency to use Mizoribine more early than the ineffective group.Drug indications note that Mizoribine should be used if DMARDs are ineffective, but it can be administered earlies than this effective, but it can be used more early.
西日本整形・災害外科学会の論文