A Comparative Study of Concentrations of Isepamicin between Venous Blood and Bone Marrow.

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Introduction:In orthopedic surgery, it is important to prevent infections, and antibiotics are used for this aim. The concentration of antibiotics must exceed MIC in the venous blood and bone marrow. In this study, we measured the concentration of isepamicin of the venous blood and bone marrow.Subjects and methods:The subjects consisted of 4 males and 2 females who underwent reconstruction of the rotator cuff. Their ages ranged from 40 to 65 (average is 56.7 years old). We administend 400mg of Isepamicin for 30 minutes and extracted the venous blood and bone narrow immediately after, 30 minutes, and 60 minutes later. The blood of the bone narrow was extracted from the surgical neck of the humerous during the operation, separated the venous blood and bone marrow at a rate of 3000/min for 10 minutes, and measured the blood plasma.Results:The concentration of Isepamicin was higher than MIC in both the venous blood and bone marrow. Side effects of Isepamicin were found in all cases.Conclusions:Isepamicin is an effective antibtic agent for orthopedic surgery.
西日本整形・災害外科学会の論文