The effect of some drugs on the conduction velocity, in toad heart muscle

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概要

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• The object of present investigation was to measure the conduction velocity of heart muscle, modifying the method of Bammer and Rothschuh. Using R-C coupled amplifier and a cathode-ray oscillograph, the conduction velocity was estimated by finding the time interval between the stimulus artefact and the action potential. The potential changes usually consisted of QRS-segment and Tspike as shown in ECG, and was influenced by the spontaneous movement, the distance of bipolar recording electrodes and the recording point. The conduction velocity related to the stimulus strength and the concentrations of some ions, especially K· and Ca··. From these results it was found that this method is one of the most excellent procedures to investigate the effect of some drugs on the conduction velocity in toad heart muscle.

• 社団法人 日本薬理学会の論文

著者

• 瀬川 富郎

  京都大學醫學部藥理學教室

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• The effect of some drugs on the conduction velocity, in toad heart muscle

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