Adrenalin及びAcetylcholinの血管作用に就て

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Using the drop-timer, designed lately by the authors, the blood vessels of the extirpated frog's leg and of the rabbit's ear were perfused by the usual laboratory technic with Ringer-Locke's solution. The mode of action of adrenaline and acetylcholine were studied by discussing the effects of some other autonomic. drugs upon the action of adrenaline and acetylcholine. Results : 1) At the beginning of the perfusion of the frog's leg-vessels, the rhythmic increase and decrease of outflow of perfusate were observed. 2) At the beginning of the perfusion of both preparations, it was often seen that the injection of adrenaline (10<SUP>-7</SUP>-10<SUP>-9</SUP>) increased the outflow, but after the preparations were stored in 0°C for 12 hrs, the increase of outflow could be seen no more; but only a decrease of outflow. 3) Acetylcholine decreased the outflow of the frog's leg-vessels almost without exception, but increased the outflow of the rabbit's ear-vessels occasionally, which responded to a decrease of outflow of the rabbit's ear-vessels occasionally, and responded to a decrease of outflow without exception after it had been_ stored in 0°C for 12 hrs. 4) Parasympathicomimetics, such as betaine methyl- and ethylesters and pilocarpine inhibited the decreasing action of adrenaline in dilute concentration, but potentiated in high concentration. Pilocarpine also inhibited the decreasing action of acetylcholine. 5) The decreasing actions of adrenaline and acetylcholine were potentiated by eserine and DFP in dilute concentration, but they were inhibited or prevented by large doses of DFP. 6) The decreasing action of adrenaline and acetylcholine were potentiated by the amall doses of atropine, but were inhibited or prevented by large doses. 7) Adrenolytics, such as priscol, privine, Dibenamine and reygostine inhibited or prevented the decreasing action of adrenaline and acetylcholine. 8) Nicotine potentiated the decreasing action of adrenaline and acetylcholine by small doses, and inhibited or prevented by large doses. From the pharmacological results above mentioned the modes of constrictor action of nicotine and acetylcholine (nicotine-like action) were qualitative similar to that of adrenaline. In discussing the details of the results, the authors concluded that nicotine and acetylcholine had the same site as adrenaline, and that the constrictor action of nicotine and acetylcholine resulted from the liberation of sympathin-like substances at the effector cell.
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Adrenalin及びAcetylcholinの血管作用に就て

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