駆虫薬に関する研究(2)-諸種駆虫薬の豚蛔虫に対する効力の比較-
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概要
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The actions of the following drugs were examined on <I>Ascaris suillus</I>. Drugs tested : Santonin, hexylresorcinol, <I>iso</I>-amylresorcinol, oil of chenopodium, thymol, naphthaline, camphor, tetrachlorethylene, carbon tetrachloride, <I>p</I>benzylphenol (allegan), allantolactone (helenin), xanthoxylum-extract and seven of thirty-six sulphides which exerted some anthelmintic effects on the earthworm, such as phenylthio-urethane, phenylthiol-urethane, <I>o</I>-methylphenylthio-urethane, <I>p</I>-oxyphenylthio-urethane, <I>o</I>-oxyphenylthio-urethane, acetylphenylthiol-urethane, and butyl ester of phenylthiocarbamic acid. Result : Hexylresorcinol shows in general the most powerful and immediate anthelmintic action on ascaris, while thymol, <I>iso</I>-amylresorcinol, oil of chenopodium, <I>p</I>-benzylphenol, and <I>o</I>-methylphenylthio-urethane have also the same actions but somewhat weaker. Among them oil of chenopodium and <I>p</I>-benzylphenol are less toxic than hexylresorcinol and in their low concentrations these anthelmintic effects are rather stronger than hexylresorcinol so that <I>p</I>-benzylphenol, newly introduced, seems likely to have the practical value for clinical use.
- 社団法人 日本薬理学会の論文