麻酔ネコのヒラメ筋における不完全強縮に対するα,β遮断薬アロチノロ-ルの作用

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The effect of arotinolol on the incomplete tetanic contractions of the cat soleus muscle was studied. Isoproterenol and epinephrine injected intravenously decreased the tension and degree of fusion of incomplete tetanic contractions of the soleus muscle in anesthetized cats. Intravenous arotinolol (>3μg/kgkg), propranolol (>30μg/kg) and pindolol (>3μg/kg) blocked the effects of isoproterenol and epinephrine, but atenolol (-300μg/kg), prazosin (0.1-10μig/kg) and phentolamine (10, 30μg/kg) did not block them. These results indicate that the receptors involved can be classified as of the β<SUB>2</SUB>-type. It is proposed that arotinolol may inhibit β<SUB>2</SUB>-adrenoceptors in the extrafusal muscle fibers of slow muscle, and thereby reduces the amplitude of tremor by changing the incomplete tetanic contractions of the muscle to the complete ones.
社団法人日本薬理学会の論文