高分子の表面修飾による機能性リポソームの設計

概要

論文の詳細を見る
For establishment of safe and effective therapy, carriers that achieve high-precision drug delivery are required. Liposomes are one of the most promising drug delivery systems. To increase usefulness of liposomes as drug delivery systems, we have attempted to provide various functions to liposomes via surface surface modification of liposomes with functional polymers. Functions of polymer-modified liposomes were based on their interactions. Therefore, surface-modification of liposomes with temperature-sensitive polymers can give temperature-responsive liposomes whose drug release is triggered by mild heating. Also, surface modification of liposomes with pH-sensitive polymers can generate pH-responsive liposomes whose destabilization is induced in weakly acidic environments. In addition, modification with several kinds of polymers with different functions can generate multifunctional liposomes. Here, we describe design, preparation and performance of functional liposomes based on the surface modification with functional polymers, such as temperature-sensitive, pH-sensitive, magnetic resonance-detectable polymers for the production of liposomes for high-precision site-specific delivery and/or intracellular delivery of bioactive molecules.