リポソ-ムにおける荷電物質の透過機構とその速度解析
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概要
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There are two kinds of permeation mechanisms through liposome membrane discriminated by the difference of permeation molecules. One is the permeation mechanism concerning the molecular sieving of ions or polar molecules such as K<SUP>+</SUP>, Na<SUP>+</SUP>, glucose etc. According to this mechanism, the molecules permeate through the boundary domains between the microclusters composed of molecules either in gel state or in liquid-crystalline state. The other permeation is for water and proton. Proton permeation mechanism is regarded as proton transfer along a network of hydrogen bonded water molecules in the hydrophobioc media of phospholipids. In this article, recent progress in the research on the mechanism are briefly reviewed together with rate studies on permeation of charged materials and related topics.
- 日本膜学会の論文