細胞内イオンによるカリウムチャンネル整流性の発現 (イオンチャネルとリセプタ-<特集>)
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概要
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Voltage-dependent block by internal Mg<SUP>2+</SUP> and Na<SUP>+</SUP>, which exist physiologically inside cells, causes the inward rectification in a number of K<SUP>+</SUP> channels. Cardiac inwardly rectifying K<SUP>+</SUP> channels differ from other K<SUP>+</SUP> channels in that Mg<SUP>2+</SUP> is effective at much lower concentrations and that with Mg<SUP>2+</SUP> at the μM level the outward open-channel currents show sublevels with one-third and two-thirds of the unit amplitude and fluctuate between sublevels. In most channels, internal Na<SUP>+</SUP> at mM concentrations reduced the unitary amplitude of the outward current in a voltage-and concentration-dependent manner without increasing the current noise, suggesting that blocking kinetics are much faster than in the block by internal Mg<SUP>2+</SUP>.
- 日本膜学会の論文