水面単分子膜人工レセプター膜界面における生理活性物質の分子認識
スポンサーリンク
概要
- 論文の詳細を見る
Monolayers at the air-water interface provide unique environments for molecular recognition. New host-guest systems utilizing such monolayers have been developed recently. Effective binding of water-soluble substrates by the hydrogen bonding interaction were found for monolayers functionalized at their hydrophilic groups with diaminotriadine, urea, orotate, Kemps acid, guanidinium and resorcinol groups. These monolayers bind polar substances such as nucleobases, nitrogen aromatics, amino acids, AMP, ATP and sugars from aqueous subphases. Their association constants, in the range of 10<SUP>2</SUP>-10<SUP>3</SUP> M<SUP>-1</SUP>, are comparable to those reported for similar systems in aprotic solvents. It is contrasting with a generally held view that the interaction in simple organic receptors is surppressed in the aqueous microenvironment, and should be brought out from unique properties of monolayer surfaces. Characteristics of molecular recognition at two dimensionally arranged monolayer surfaces are discussed.
- 日本膜学会の論文