細胞分化と細胞膜複合糖質 : 赤血球の分化と膜糖タンパク質の変化

概要

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The human erythrocyte membrane is best characterized biomembrane in terms of its structure and function on a molecular bases. The membrane glycoproteins can be classified into two groups, which are sialoglycoproteins and polylactosaminylglycoproteins. The former includes glycophorin A, B and C, and the latter includes Band 3, Band 4.5 and glucose transporter. These two classes of glycoproteins differ from each other in carbohydrate structure, in the modes of orientation in lipid bilayer, and in their functions.<BR>The cell surface glycoproteins are significantly changed during the course of erythroid differentiation. The characterization of glycoprotein by cell surface labeling and endo-β-galactosidase treatment revealed the following stage-specific membrane glycoproteins : Gp 80 for the progenitor cells, Gp 95 for proerythroblasts, and Gp 105 for erythroblasts. Considerable evidences suggests that the microenvironment, including cell to cell interactions, play a role in controlling the differentiation of haematopoietic cells. The possibility that of specific surface glycoproteins are involved in cellular recognition is also discussed.
日本膜学会の論文