REP投与による急性腎不全とINH併用時の肝障害について

概要

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Recently, rifampicin (RFP) has been regarded as one of the most effective anti-tuberculous agent and has been widely used. Although many papers have been published recently concerning the adverse effects of RFP, one of the most serious one, among them, is the acute renal failure. We experienced one case who was administered 450 mg RFP daily and suffered from acute renal failure.<BR>Recently, liver dysfunction induced by RFP and isoniazid (INH) has been paid much attention. Twelve cases (25.6%) out of 47 cases who were admitted to our department and administered both RFP and INH showed the slight liver dysfunction. It seems to us that such a liver dysfunction is not so severe and occurs at an early stage from the beginning of drug administration, and usually almost all of patients show the quick recovery from the liver dysfunction while continuing the administration of these drugs.
一般社団法人日本結核病学会の論文