ガス曝露下における結核化学療法剤の効果に関する実験的研究 : 第1編結核菌発育阻止効果について

概要

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It was found in general that the activities of antituberculous agents on the growth of tubercle bacilli was attenuated when they were cultured under unfavourable conditions for the growth of bacilli. In this experiment, the air in environment of culture media of tubercle bacilli was replaced by either of N2, CO2 or O2, and the antimicrobial activities of antituberculous agents were examined. The experiments were performed by using the silicone-coated slide culture method with Kirchners medium. Mycobacterium tuberculosis strain H37RV was used as the test strain. The minimal inhibitory concentration (MIC) of streptomycin (SM), kanamycin (KM), para-aminosalicylic acid (PAS), isoniazid (INH) and rifampicin (RFP) was determined. There was no growth of tubercle bacilli in any sample, regardless of the kind of drugs used, the length of the cultivation time, and the kind of gas. In conclusion, it was proved by this experiment that conditions used in this study was quite inadequate for the growth of tubercle bacilli.
日本結核病学会の論文