Studies on Mycobacterium Tuberculosis Showing Extremely High Resistance to SM, PAS and INH.
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Resistance to SM was measured on Mycobacterium tuberculosis isolated from 423 cases ofpulmonary tuberculosis admitted to the NationalKanagawa Sanatorium during the period fromJanuary 1959 to June 1960, and resistance toPAS and INH was measured on Mycobacteriumtuberculosis isolated from 377 cases admitted tothe same sanatorium during the period fromJuly 1959 to December 1960. Ogawa's eggmedia was used for drug susceptibility testeither by direct or indirect method, and m oreover, Ogawa's egg media containing severalcombination of SM, PAS and INH with variousconcentration was used to determine the doubleand triple resistance to SM, PAS and INH.<BR>The results were the following:<BR>1. Among 423 strains tested for SM, 20showed extremely high resistance to SM; 4 wereresistant to 5, 000γ/ml, 3 were resistant to10, 000γ/ml and 13 were resistant to 50, 000γ/ml. Most of these 20 cases were far advancedcavitary tuberculosis, and total amount of SMused in the previous treatment exceeded 100, gr. in the majority of the cases. In the previous treatment, SM was used singly in 5 cases, and combined with other drugs in 15 cases.During the course of treatment, 15 showed nochanges, 2 deteriorated and 3 improved. Doubleand triple resistance was measured on 14 strainsshowing resistance to SM at 10, 000γ/ml andover, and 7 strains showed double or tripleresistance to SM, PAS and INH. In this case, strains were considered to be resistant, ifgrowth of tubercle bacilli on drug containingmedia amounted to 75% of the control media.<BR>2. No strains showed extremely high resistance to PAS.<BR>3. Among 377 strains tested for INH, 6showed extremely high resistance to INH; 4were resistant to 100γ/ml and 2 were resistant to 200γ/ml. Most of these 6 cases were faradvanced cavitary tuberculosis, and receivedINH more than 200 gr. In the previous treatment, INH was used singly in 1 case, andcombined with othes drugs in 5 cases. Duringthe course of treatment, 4 showed no changes, and 2 deteriorated. All strains showing extremely high resistance to INH were negativein catalase and peroxydase reactions.<BR>4. Only 1 strain showed extremely highresistance to both SM and INH, and all otherstrains showed extremely high resistance singlyeither to SM or INH.
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- Studies on Mycobacterium Tuberculosis Showing Extremely High Resistance to SM, PAS and INH.