ナイアシン・テスト陽性の劣性発育抗酸菌二宮S1株に関する知見補遺
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In order to identify the Ninomiya S<SUB>1</SUB>, strain of a mycobacterium associated with pulmonary disease in man (Urabe and Kawai, 1957), various biological and biochemical characteristics were investigated. Th e cultures used in this study were Ninomiya S<SUB>1</SUB> strain, and H<SUB>37</SUB>Rv strain of Mycobacterium tuberculosis, Ravenel strain of M. bovis, Kirchberg strain of M. avium and Okayama strain of intracellulare as the control. M. The Ninomiya S<SUB>1</SUB> stra i n showed the following characteristics: Colonies on 1% Ogawa egg medium and 7 H 10 medium were nonphotochromogenic, small, flat, thin and smooth in appearance, but not easily emulsifiable (Sr-type). In Kirchner's liquid medium, the growth remained on the bottom of the test tube and pellicles were not formed after six weeks' incubation at 37`C. The growth in Tween-albumin broth was to some extent better than that in Kirchner's liquid medium. The organism gave a positive cord formation and neutral red test. Growth was observed at 33°C and 37°C, and not at 22°C and 42°C. The organism was susceptible to 125 mcg per ml of hydroxylamine, 1 per cent of sodium desoxycholate and 0.1 M of sodium nitrite, whereas resistant to 62.5 mcg per ml of hydroxylamine, 0.05 per cent of pyronin, 0.5per cent of sodium desoxycholate, 10 mcg per ml of TCH and 1, 000 mcg of PAS. PAS was not decomposed. The organism gave a positive niacin test, a positive nitrate reductase, a weakly positive semiquantitative catalase, a negative 68°C heat stable catalase, a negative acid phosphatase and a negative 70°C heat stable acid phosphatase. None of three-day, 2-week and 3-week arylsulfatase tests were positive. The amidase was positive for urease and nicotinamidase, while negative for acetamidase, benzamidase, isonicotinamidase, pyrazinamidase, salicylamidase, allantoinase, succinamidase, malonamidase, acrylamidase and propionamidase. Of 16 carbohydrates, only trehalose was decomposed. Of 10 organic acid salts, sodium (sod. ) acetate, sod. pyruvate, sod. propionate, and sod. lactate were utilized. The Ninomiya S, strain is differentiated from A l. avium and Battey bacillus in respect of cord formation, neutral red test, growth temperature, susceptibility to hydroxylamine and sod. desoxycholate, and 68°C heat stable catalase. Also, the organism is differentiate d from M. bovis in a positive niacin test, growth on 10mcg TCH medium, a positive nicotinamidase and a negative arylsulfatase. When the present results on 67 characters studied were a n alyzed according to the method proposed by Sneath, similarity values of the Ninomiya S<SUB>1</SUB> strain with M. tuberculosis, M. bovis, M. avium and Battey bacillus were 90%, 58%, 45% and 31%, respectively. These findings mentioned above would support that the N i n omiya S<SUB>1</SUB> strain might be a human type of mycobacteria. Moreover, considering from a standpoint of its colonial morphology and growth characteristics, the Ninomiya Si strain was likely to be a variant of M. tuberculosis.
- 一般社団法人 日本結核病学会の論文
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