サルコイドージスとクベイム反応-自験例の成績を中心として-

概要

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The aim of this study was to elucidate the sensitivity and specificity of the Kveim test in sarcoidosis. Between 1968 and 1978 we performed 119 tests. The results were analysed by dividing the term into two; A group between 1968 and 1974 and B group between 1975 and 1978. The results obtained indicate the usefullness of this test, and are summarized as follows: 1. 38 cases were positive out of 103 histologically confirmed cases (36.9%). 15 cases were positive out of 56 cases (26.8%) in A group, while 23 cases positive out of 47 cases (38.9%) in B group. Positive rate in B group was always higher than that of A group even if subjects are subdivided into several categories by factors such as age, chest X-P, extrapulmonary lesions and PPD skin test. 2. Correlation between decreased PPD reactivity and Kveim positive test was observed. 3. Positive rate depended on the lot of test suspension. Test suspensions satisfying criteria defined by Silzbach were few in number, though such suspensions have been increasing. 4. Positive rate did not correlate with lymphocyte count as well as DNCB skin reaction. 5. Positive reactivity was not found in non-sarcoid subjects.