BCG接種液の腹腔内接種事故例の臨床および細菌学的研究

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A 45 years old hausewife passing by a BCG vaccinator was accidentally inoculated with BCG vaccine for transcutaneous use into her left side abdominal cavity. A vaccine was inspired into 10 ml syringes, and the dose of vaccine inoculated was not clear. Though only slight abdominal pain and fullness of abdomen were felt on her way home, about 7 days later, her temperature rose to 38-39°C.14 days later, a subcutaneous abscess appeared at the site of inoculation, and thereafter, exudate was also proved in Douglas cavity. These symptoms recovered gradually by the treatment with antituberculous drugs. 8 months after the accident, she underwent an operation for removal of uter u s myoma. Findings of the abdominal cavity were as follows: the sigmoid flexure was fixed by fibrous adhesion, but the large and the small intestines were intact. Mesenteric lymph nodes were not enlarged. The peritoneum at the site of inoculation revealed a scar but no adhesion. Acid-fast bacteria isolated from the pus and t h e ascites showed negative reactions in the nitrate reduction or heat-stable catalase test, but positive in catalase activity. They had the same reactions in niacin test as BCG. Guinea pigs and rabbits injected subcutaneously with 0-.05 mg of cultures of the two strains: Mycobacterium tuberculosis and the isolate from ascites, became positive to tuberculin test. Animals were sacrificed at 11 weeks (guinea pigs) or 13 weeks (rabbits) after injection. Those inoculated with the isolate showed no tubercles in their spleen, liver, lungs and lymph nodes, and acid-fast bacilli were not recovered from these organs, while guinea pigs inoculated with M. tuberculosis showed tubercles in their organs and M. tuberculosis were recovered. From these results it was concluded that the isola t es were low-virulent mycobacteria and compatible with BCG.
一般社団法人日本結核病学会の論文

BCG接種液の腹腔内接種事故例の臨床および細菌学的研究

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