結核菌におけるアミノグルコシッドおよびポリペプタイド系薬剤相互間の交叉耐性について

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The variable manifestations of tubercle bacilli on the attitude of cross-resistance among aminoglucoside and polypeptide antibiotics, especially on enviomycin (EVM) and lividomycin (LVM), were evaluated in vitro and reported by our colleagues. Although there have been many reports on the cross-resistance among aminoglucosides and polypeptides, most of them have only dealt with the tubercle bacilli definitely resistant to some degree, and only a few of them successively evaluated those resistant in various degrees to each drug. In this paper, the degree of cross-resistance among streptomycin (SM), kanamycin (KM), viomycin (VM), capreomycin (CPM) and enviomycin (EVM) are evaluated in vitro with the bacilli resistant in variable degrees to each drug obtained by the successive transfer of a drug containing medium with a serially increasing concentration method. The rapidity of acquiring resistance was in the following order of: SM=KM>EVM>CPM>VM These are to be summarized as follows: 1. the rapid appearance of high grade cross-resistance, 2. the rapid appearance of high grade cross-resistance after a certain period of no cross-resistance, 3. the appearance of high grade cross-resistance after a certain period of middle grade cross-resistance, 4. the rapid appearance of middle grade cross-resistance and no changes thereafter, 5. showing middle grade cross-resistance for a certain period of time, then the appearance of high grade cross-resistance, 6. no emergence of cross-resistance throughout. In conclusion, it can be said that the development of mutual cross-resistance among aminoglucoside and polypeptide antibiotics is influenced by the respective resistance of drug-resistant bacilli and by the combination of each drug for the emergence of the resistant bacilli.
日本結核病学会の論文

結核菌におけるアミノグルコシッドおよびポリペプタイド系薬剤相互間の交叉耐性について

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