非定型抗酸菌に対する主としてCephem系抗生物質の試験管内制菌効果について
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The susceptibility of atypical mycobacteria (mainly <I>Mycobacterium-avium-M. intracellulare</I> Complex) to Cephem and other antibiotics was studied using Dubos Tween albumin liquid medium.<BR>The atypical mycobacterial strains tested were chosen from 46 strains including 6<I>M</I>. <I>kansasii</I>, 4<I>M. scrofulaceum</I>, 25<I>M. avium-M. intracellulare</I> Complex, and 11<I>M. fortuitum</I> Complex.<BR>Thirteen Cephem antibiotics [Cephalothin (CET), Cephaloridine (CER), Cefazolin (CEZ), Cefoxitin (CFX), Cefotiam (CTM), Cefsulodin (CFS), Cefmetazole (CMZ), Cefotaxime (CTX), Ceftizoxime (CZX), Cefoperazone (CPZ), Cefmenoxime (CMX), Latamoxef (LMOX), Cefpir amide (CPM)] and five other antibiotics [Minocycline (MINO), Ampicillin (ABPC), Piperacillin (PIPC), Lincomycin (LCM), Sulbenicillin (SBPC), Fosfomycin (FOM)] were studied.<BR>Among the Cephem antibiotics studied, CER and CMX, which showed about the same MICs as RFP, inhibited well over 90% of the strains of <I>M. avium-M. intracellulare</I> tested at the concentration of 3.13μg/m<I>l</I>. These two antibiotics were followed by CEZ, which inhibited around 70% of the strains at the same concentration. Among the other antibiotics, MINO demonstrated a moderate <I>in vitro</I> activity against <I>M. avium-M intracellulare</I>.<BR>The MICs of these drugs seem to be not satisfactory enough to expect unequivocal effects in future clinical trials, however, it is worthwhile to continue to investigate further for the candidates in the multiple-drug chemotherapies.
- 日本結核病学会の論文
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