EXPERIMENTAL STUDIES ON EFFECT OF COMBINED USE OF 1314Th AND INH TO INH-RESISTANT TUBERCLE BACILLI:2. Combination effect in the experimental tuberculosis of mice
スポンサーリンク
概要
- 論文の詳細を見る
Using CF #1 male mice infected with 50γ/ml-INH-resistant H<SUB>37</SUB>Rv, the author examined the effect of combined use of 1314 Th and INH to INH-resistant tubercle bacilli.<BR>Mice were divided in the following five groups.<BR>Group 1: No treatment.<BR>Group 2: Treated with 500γ of INH every day.<BR>Group 3: Treated with 500γ of 1314Th every day.<BR>Group 4: Treated with 500γ of 1314Th and 100γ of INH every day.<BR>Group 5: Treated with 500γ of 1314Th and 500γ of INH every day.<BR>Consequently, the tuberculous involvement of the fifth group was the slightest both in the number of viable units recovered from the lung and in the histological findings. There was observed no significant difference between the third and the fourth group.<BR>These results in vivo are quite in agreement with those in vitro described in the author's first report. Thus the effect of 1314Th is enhanced by the combination with INH, even in the case of INH-resistant tubercle bacilli.
- 一般社団法人 日本結核病学会の論文