POLAROGRAPHIC STUDIES ON α-ETHYL-THIOISONICOTINAMIDE-SULPHOXIDE

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概要

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• We have reported in previous papers that α-ethyl-isonicotinamide and α-ethyl-isonicotinic acid were detected in rabbit urine orally administered with α-ethyl-thioisonicotinamide (1314Th).<BR>Kane emphasized in his reports that 1314 Th-sulphoxide existed in human and rabbit serum treated with 1314 Th.<BR>Therefore, in this report, we have studied on the polarographic properties and stability of 1314 Th-sulphoxide synthesized by Prof. H. Taniyama, and on the comparison of 1314 Th-sulphoxide-solution with the human urine administrated with 1314 Th, in which unkown waves appeared between -0.5v. and-1.0v. on the polarographic method.<BR>Results:<BR>1) As in the Kane's reports, 1314 Th-sulphoxide in water solution gave two waves with a separation of half wave potentials of-O.5v.--1.0v., and with wave heights in ratio 1: 2 (the ratio of the first wave: the second wave in 1314 Th-sulphoxide).<BR>2) 1314 Th-sulphoxide is unstable for heating; when its solution was incubated at 37°C for 3 weeks or at 100°C for 30 minutes, its specific waves were diminished and disappeared.<BR>3) With the polarographic method, the α-ethylisonicotinamide or α-ethylisonicotinic acid is easily recognized in the mixture or rabbit liver homogenate with 1314 Th-sulphoxide incubated at 37°C for 15-30 minutes.4) The polarographic waves in the mixed solution of 1314 Th-sulphoxide with the isonicotinic acid, isonicotinamide or isoniazide showed that the ratio of first half wave potential to second wave of 1314 Th-sulphoxide did not become 1: 2.<BR>5) From the fact that the polarographic waves of the human urine treated with 1314 Th are identical with those of 1314 Th-sulphoxide in the above experiments, it is considered that in the human urine treated with 1314 Th there exist a-ethylisonicotinamide, α-ethylisonicotinic acid and a small dose of α-ethylisonicotinamide sulphoxide.

• 一般社団法人 日本結核病学会の論文

著者

• 山崎 正保

  国立療養所刀根山病院

• 古川 佳也

  国立療養所刀根山病院

• 奥田 良雄

  国立療養所刀根山病院

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