新たに開発されたニューキノロン系薬剤Fleroxacin, LomefloxacinおよびSparfloxacinの結核菌に対する<I>in Vitro</I>抗菌活性
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<I>In vitro</I> antituberculous activities of three newly developed quinolones, fleroxacin (FLRX, AM-833), lomefloxacin (LFLX) and sparfloxacin (SPFX, AT-4140) were evaluated comparison to that of ofloxacin (OFLX) using <I>M.tuberculosis</I> strains isolated from patients and the Ogawa egg medium.<BR>SPFX was apparently more active than OFLX, but both FLRX and LFLX were less active.SPFX inhibited completely the growth of all 20 strains of <I>M.tuberculosis</I> isolated from patients who were not previously treated with OFLX in a concentration of 1.25 ug/<I>ml</I>. However, this agent inhibited the growth of only 4 strains (28.6%) of 14 OFLXresistant <I>M.tuberculosis</I> in a concentration of 1.25, u, g/m/, suggesting a partial cross-resistance between SPFX and OFLX.
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