2,3糸状菌抽出画分の生物活性,特にAspergillus fumigatus毒素について

概要

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Studies were made on the characteristics of crude toxin produced in the culture filtrate and cells of Aspergillus fumigatus, as compared with extracts of Aspergillus niger and Penicillium chrysogenum.(1) Mouse lethality, hemolyticity and dermonecrosis were demonstrated in crude toxic fractions isolated from the cells and culture filtrate of A. fumigatus by a mild method, but not in the purified galactomannan and lipopolysaccharide fraction from the same organism. The fractions isolated from P. chrysogenum by the similar method had an exceedingly weak toxicity. No fractions from A. niger possessed such biological activity at all.(2) After treatment with formalin or phenol, the toxic fraction of A. fumigatus decreased in activity in mouse lethality and hemolyticity to a large extent, and in dermonecrosis to 50%.(3) A. fumigatus toxin was neutralized, to the same extent, by antiserum obtained against the toxin or toxoid. The fractions of P. chrysogenum showed a weak cross-reactivity to antiserum against A. fumigatus.(4) In the crude toxic fraction of A. fumigatus, there were such enzyme activities as amylase, gelatinase, caseinase, collagenase, acid phosphatase, ATPase, and hyaluronidase.
日本細菌学会の論文