溶原ジフテリア菌の毒素原性に関する研究-1-
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概要
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Previously Hatano and Kurokawa reported that the majority of doubly lysogenic strains of C. <I>diphtheriae</I> seemed to be more toxinogenic than singly lysogenic ones. No systematic investigation on the magnitude of toxinogeny of various singly lysogenic strains has been reported yet.<BR>This paper deals with the toxinogeny of various lysogenic strains derived from C4, applying a relatively simple technique of toxin-antitoxin reactions in the agar gel. The following results were obtained.<BR>1. There seemed to be a correlation between the toxinogeny and the size of halo formed around the colony grown on an agar culture plate containing antitoxin. This method is both simple and easy to roughly estimate the toxinogeny of strains of diphtheria bacilli.<BR>2. The magnitude of toxinogeny varied with different lysogenic strains, even within strains carrying, the same type of prophage, while the majority of their clones were proven to be stable through several, passages.<BR>3. The magnitude of toxinogeny seemed to be independent of its carrying prophage type, and could not be transfered with the phage to an other strain. Factor or factors that regulated the magnitude of: toxinogeny of lysogenic strains remained undetermined, but it may be probably regulated by host cell itself.
- 日本細菌学会の論文