植物成分の細菌発育阻止作用に関する研究-2-
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By treating the extract of A. Sativum with dehydrated alcohol and further fractionating this extract with ether. it has been found that a soluble portion of the fractions has an inhibitory action on the bacterial. growth. Therefore, this fraction is added to the culture medium and to this medium various strains of bacteria are inoculated and cultured for several successive generations to obtain each tamed strain that grows up to the concentration containing 50mg/ml of them. These tamed strains are employed for the purpose of studying the changes in their susceptibility to three antibiotics, penicillin (Pc), streptomycin (SM) and trichomycin (TM). The results are as follows.<BR>1. Susceptibility of the tamed <I>Staph. aureus</I> 209 P to Pc is decreased down to 500-fold that of the original strain, but its susceptibility to SM is not so markedly altered. In the case of tamed E. coli itssusceptibility to SM is down to about 10-fold that of the original strain and likewise in C. albicane the susceptibility to TM is about the same showing no marked change.<BR>2. In order to see synergistic effect of the soluble fraction of the A. Sativum extract with antibiotics, Pc, SM, and TM at different concentrations are mixed in common agar medium and Sabouraud agar medium and to such media is added the fraction in the concentration at which it does not inhibit the growth of the bacteria (the original strain) serving for this purpose. In the ensuing bacterial culture it has been found that no synergistic action at all can be recognized with any of these antibiotics.
- 日本細菌学会の論文
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