The biosynthetic pathway of L-ascorbic acid in Euglena gracilis Z.

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概要

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• D-Glucose and D-galactose were the starting materials of L-ascorbic acid biosynthesis in Euglena gracilis as evidenced by feeding experiments of unlabeled and labeled sugars, but D-glucose was the more effective precursor. The addition of various acid derivatives of D-glucose and D-galactose, with the exception of D-glucono-δ-lactone, considerably augmented L-ascorbic acid formation. D-Galacturonic acid and L-galactono-γ-lactone showed greater effects than did D-glucurono-γ-lactone and L-gulono-γ-lactone. The results of isotopic dilution experiments also showed the preference for the galacto-configuration. Fed U-14C-D-glucose was transformed into labeled D-galacturonic acid to a greater extent than into labeled D-glucuronic acid, and added D-galacturonic acid only caused extensive accumulation of labeled D-galacturonic acid. These results together show that the pathway involving D-galacturonic acid and L-galactono-γ-lactone is the major one, the one involving D-glucuronic acid L-gulono-γ-lactone being the minor one. A likely pathway for L-ascorbic acid biosynthesis in Euglena is proposed in the Scheme, which thus involves uronic acid intermediates and configurational inversion.

• 財団法人 学会誌刊行センターの論文

著者

• 北岡 正三郎

  Department of Agricultural Chemistry, University of Osaka Prefecture

• 中野 長久

  Department of Agricultural Chemistry, University of Osaka Prefecture

• 重岡 成

  Department of Agricultural Chemistry, University of Osaka Prefecture

• 北岡 正三郎

  Department of Agricultural Chemistry, Faculty of Agriculture, University of Osaka

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