Work Capacity after Iron Treatment as a Function of Hemoglobin and Iron Deficiency

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概要

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• The relative importance of hemoglobin (Hb) and non-Hb iron for physical work capacity was studied in 45 adult male and female subjects, with a range of Hb and serum iron levels. Maximal work capacity, heart rate, venous blood lactate and serum protein were measured before and after 1 week of treatment with Imferon, i.v. Even though some non-Hb related effects on parameters indicative of maximal work capacity were found, the main factor was Hb related. Subjects with low Hb-high serum iron worked longer than ones with low Hb-low iron. When the work performed was similar, the marginal Hb-low iron group had a higher blood lactate concentration than the high Hb-high iron and marginal Hb-high iron groups. The coefficient of correlation between serum iron and post-exercise lactate levels was -0.41 (p<0.05). Even though neither of these groups showed a Hb response within 1 week of iron treatment, the initial low serum iron groups had significantly lower heart rates at a given work load relative to subjects with high iron but with a similar Hb level. This occurred both at rest and during light to heavy exercise. These results suggest that a rather rapid benefit of iron treatment is gained in iron-deficient subjects with severe and moderate anemia which cannot be accounted for by Hb changes. Although the primary factor which affects the physical work capacity of iron-deficient anemic subjects seems to be the Hb level, there also seems to be a significant non-Hb related effect of iron treatment as well.

• 財団法人 学会誌刊行センターの論文

著者

• 大平 充宣

  Department of Physiology and Biomechanics, National Institute of Fitness and Sports

• 井川 幸雄

  Department of Laboratory Medicine, The Jikei University School of Medicine

• Edgerton V.

  Department Of Physiological Science And Neurobiology University Of California Los Angeles

• SENEWIRATNE B.

  Department of Medicine, University of Sri Lanka

• Gardner G.

  Department Of Cell And Cancer Biology National Cancer Institute

• GUNAWARDENA K.

  Department of Medicine, University of Sri Lanka, Sri Lanke

• 大平 充宣

  Department of Kinesiology University of California

• 大平 充宣

  Department of Kinesiology, University of California, Los Angeles

• GARDNER G.

  Department of Kinesiology, University of California, Los Angeles

• 井川 幸雄

  Department of Clinical Medicine, The Jikei University School of Medicine

• EDGERTON V.

  Department of Kinesiology University of California

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