Oral florid papillomatosisの1例

概要

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Oral florid papillomatosis (OFP) was first described by Rock and Fisher in 1960.It is a relatively rare lesion and looks clinically like a leukoplakia or a malignant tumor.<BR>A 75-year-old woman visited our clinic with a complaint of white lesions existing on the left side margin of the tongue, the alveolar ridge of left lower molar region and the left buccal mucosa.<BR>The clinical and pathologic diagnosis of leukoplakia was made.The lesions were excised after the treatment for 13 months with Etretinate (orally, total dose of 3080mg), Pepleomycin (intravenously, 90mg) and Bleomycin (by ionophoresis, 90mg).However, a recurrence was obserbed on all excised areas 6 months later.<BR>Repeated pathologic examinations were carried out and finally the diagnosis of OFP was obtaind.10mg of Bleomycin (intramuscularly) was administered weekly for 6 weeks.The treatment was very effective and a small lesion remaind on the buccal area.The patient has been followed-up with a treatment of repeated cryotherapy.