2450MHzマイクロ波による口腔癌の温熱療法の試み
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概要
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Thermotherapy by 2450 MHz microwaves was performed on oral cancer patients and its effectiveness was analyzed and evaluated.<BR>Subjects were 7 primary oral cancer patients (4 lower gum cancer, 2 buccal mucosa and 1 oral floor) and 5 recurrent cancer patients (3 with cheek lesion and 2 with neck lesion). Heat was generated by a microwave apparatus of 2450 MHz.<BR>Seven cases which received intraoral thermotherapy on primary lesions were treated in combination with radiation and bleomycin. Thermotherapy was performed twice a week, up to 5-8 times in total, applyied immediately after the radiation therapy. Intraoral applicator was a flexible leakage-type coaxial applicator 2-4 mm in diameter and 40-90 mm in length. It was modified depending on each tumor size and shape. Tumor surface was heated to 42-45°C for 30-50 minutes and the heat distribution pattern of each modified applicator was checked using Phantom Model. Of the seven lesions, 6 (85.7%) showed complete regression (CR) and one showed partial regression (PR). Histological examination was made on five cases which received surgical tumor resection. Among them, one was grade III and the rest were grade IIb by Simosato's criteria. Tumor necrosis and mucosal reaction were seen at the heated site from the early stage of treatment and the thermotherapy was obviously effective.<BR>Five recurrent cancer patients received extraoral thermotherapy without radiotherapy on the cheek or neck lesions using the non-contact type applicator. Tumor necrosis was limited to the surface area and the regression effect was minimum which might be due to the lack of combination therapy of radiation.<BR>Thermotherapy seemed effective for the oral cancer when used in combination with radiation. However, more clinical experience is needed to evaluate the usefullness of this treatment.
- 社団法人 日本口腔外科学会の論文
社団法人 日本口腔外科学会 | 論文
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