Antitumor effects of radiofrequency (RF) hyperthermia on hamster buccal mucosa carcinoma.
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The effects of RF hyperthermia on hamster oral carcinomas were studied in their primary sites and in their lymph node metastasis.<BR>Transplantable squamous cell carcinoma (O-1N) with a high metastatic potency was grown up to 8 mm in diameter in the buccal pouch of the hamster. A total of 75 tumors were served for experiments: 65 tumors were heated once by the 13. 56 MHz RF wave for 40 min (single heating group, SH) at 42, 43, and 44°C, and 10 tumors were heated at 43°C 4 times during 2 weeks (repeated heating group, RH). In the SH group, tumor size of the primary site was not significantly changed until 10 days after heating at 43 and 44°C. However, no inhibition of the tumor growth was obtained at 42°C Complete disappearance of tumor cells was confirmed histopathologically in 2 of 12 tumors (17%) heated at 43°C and 2 of 20 tumors (10%) heated at 44°C. Vascular disturbance was characteristic histology of the tumor tissue just after heating at 43°C. Tumor cell necrosis appeared focally on the first day after heating. On the second and third days, necrotic changes became extensive across the tumor site. On the fourth day, tumor nests reappeared with fibrous stroma at the periphery of the necrotic foci, and thereafter, they maintained proliferation to form larger masses until the end of the experimental course. In the RH group, the tumor growth was much more inhibited until 21 days after the first heating than that of the SH group, and complete disappearance of the tumor was histologically confirmed in 4 of 10 tumors (40%). Frequency of metastasis of the carcinoma to cervical lymph nodes was reduced to 50%(5 of 10 tumors), whereas metastasis was observed in 100 (90)% of the control groups.<BR>The findings suggest that our single heating system at 43°C had transient effects on the hamster carcinoma growth and that the anti-tumor effect was enhanced by the repeated heating. Hyperthermia could possibly inhibit cervical lymph node metastasis of the carcinoma.
- 社団法人 日本口腔外科学会の論文
社団法人 日本口腔外科学会 | 論文
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