白血病患者の口腔粘膜潰瘍に関する研究 : 血液凝固第XIII因子, 血漿fibronectin,α<SUB>2</SUB>-plasmin inhibitorの変動を中心に
スポンサーリンク
概要
- 論文の詳細を見る
Plasma levels of factor Xifi and its substrates [plasma fibronectin (PFN) and α<SUB>2</SUB>-plasmin inhibitor (α<SUB>2</SUB>-PI)] were measured in leukemia patients with intractable oral mucosal ulcers to study the implications of these parameters in ulcer formation and healing. The findings were as follows:<BR>1. Oral mucosal ulcers appeared predominantly on the buccal surface of the gingiva at the lower molars and at the margin of the tongue.<BR>2. Regarding the relationship between oral mucosal ulceration and chemotherapy agents, the incidence of ulcers was higher when Ara-C, ADM, DNR, VCR or PSL were administered.<BR>3. There was no significant difference in the plasma factor XIII level between healthy individuals and leukemia patients without ulcers, while PFN and α<SUB>2</SUB>-PI levels were slightly higher in the latter.<BR>4. Factor XIV PFN and α<SUB>2</SUB>-PI levels were significantly lower at the time of oral mucosal ulcer formation than in the absence of an ulcer.<BR>5. The platelet count was significantly lower in the presence of an oral mucosal ulcer than in its absence.<BR>6. There was no significant difference between the time of oral mucosal ulcer formation and absence of ulcer in terms of plasma fibrinogen (Fib) level, WBC count or neutrophil count.<BR>7. The CRP level was significantly higher at the time of oral mucosal ulcer formation than in the absence of such an ulcer, while the T-P level showed no significant difference between the presence and absence of oral mucosal ulcer.<BR>8. The incidence of ulcer formation was higher in patients with a WBC of <1, 000/mm<SUP>3</SUP> and a neutrophil count of <500/mm<SUP>3</SUP>.<BR>9. No correlation was noted between the factor XIII level, the α<SUB>2</SUB>-PI level, the PFN level and the platelet count at the time of oral mucosal ulcer formation.<BR>10. A positive correlation was shown between factor XIII and PFN levels, between the α<SUB>2</SUB>-PI and Fib. levels, between the factor XIII level and platelet count, and between the factor XIII and T-P levels in the absence of an oral mucosal ulcer.<BR>Various blood parameters were thus measured in leukemia patients in the presence and absence of ulcerous lesions of the oral mucosa and the results suggested that factor Xifi and related factors forming its substrate may play a role in the development and healing of ulcers.
論文 | ランダム
- 地域づくりへの挑戦(117)豊能地区5市町の合同ホームページ開設について--広域的地域情報通信ネットワーク
- 地域づくりへの挑戦(113)池田らしい組織づくりへの取組について
- 〔大阪府池田〕市民公募による無給のボランティア推進室長が就任〔含 ボランティア推進室長に就任した梶田清一氏に聞く〕
- 2000カ所を突破したGH整備状況から見えてくるもの
- Part1 DATAで明らかにする介護保険事業の課題 対象者が十分特定されず現場に矛盾と混乱生ず 利用者本人に着目した計画・運営の見直し急務 (特集 介護保険制度は機能しているのか)