Chaetomium gracile由来のDextranaseによるin vitroの歯垢溶解効果ならびに洗口液および歯磨剤での臨地試験成績-1-

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The lower level of effective dextranase units in clinical tests was determined and its effect on the reduction of dental plaque was confirmed using the dentifrice containing 2000 units/g of Chaetomium gracile dextranase.<BR>In vitro, reducing sugar was released from dental plaque by 500 units dextranse and its release incresed linearly to about 2000 units. Clinically, by rinsing for 1 min. with mouthwash containing 2000 units of dextranase, a statistically significant amount of reducing sugar was released in the mouth. However, 500 units of dextranase had no effect. These results suggest that the lower level of effective dextranase units is between 500 and 2000 units.<BR>Moreover, 2 groups of 15 subjects each aged 20 and 50 used dextranase (2000 units/g) and placebo dentifrices for 2 weeks. The plaque index of dextranase dentifrice group was reduced 61.6 and 74.7 per cent after 1 and 2 weeks, respectively. But in the placebo dentifrice group reduction rates were less, being 38.5 and 41.5 per cent, respectively. Between 2 groups, there was a statistically significant difference (p<0.01), and the effect of dextranase (2000 units/g) dentifrice on the reduction of dental plaque was confirmed.<BR>However, the effect of dextranase on the gingival index was slight and not statistically significant.
有限責任中間法人日本口腔衛生学会の論文