口腔内環境と歯周疾患との関連性に関する研究-2-
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概要
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One of the causative agents the periodontal diseases could be induced sometimes by the changes of circumstances in oral cavity, and it might be vice versa, so many investigators have already informed on this sort of study. While biochemical studies relating to this matter are being active in these days, subsequently, it is reported that the pH of saliva or salivary ammonium amount are closely related to the periodontal diseases.<BR>On the dental caries which is another one of the 2 largest diseases in oral cavity, the studies on the dental caries activity have been briskly undertaken together with the investigations for the disintegrative mechanisms and the resistant factors, besides, it could be found few works on the periodontal disease activity.<BR>The author just then interested in this problem on the"Periodontal disease activity", of which term had been proposed by Mashimo et al (1962), and the salivas of periodontal diseases' patients has been examined bacteriologically and biochemically. Consequently, it was observed that the symptomatic degree of periodontal disease closely related to the activity of proteolytic enzyms come from the oral microorganisms indigenous to saliva, moreover, this fact was verified by means of the statistical observation.<BR>The results could be summed up as follows:<BR>1. The testing procedures for the proteolytic activity of human contaminated saliva was devised due to employing the hide powder for substrate and measuring the results by ninhydrin test. The experimental salivas were collected with particular terms at just before lunch, of which procedures were not followed in the former steps.<BR>2. It could be recognized that there were distinctly discrepancies between the salivas of normal controls and of the periodontal diseases, and that the degree of proteolytic acitivity was directly proportional to the symptomatic status of periodontal disease.<BR>3. According to the clinical experiments employed this technique, the salivary proteolytic activities were classified to 3 different types as follows:<BR>A) After treatment, the activity increased for 4 to 5 days, gradually decreased after that, and it became negative by the 30th day.<BR>B) After treatment, it rapidly decreased for 3 to 4 days, increased again and was restored up to the former level.<BR>C) This type showed irregular curve and rather increase after operation.<BR>All cases in A-group checked no abnormal components in the urine, B and C-groups showed various abnormal components in the urine.<BR>4. It was observed the relationship of this activity with the salivary buffer capacity, namely, the saliva of the high proteolytic activity demonstrated large buffer capacity, generally the pyorrheas' saliva showed the large capacity.<BR>Judging from these results, it could be trusted that ex amining the proteolytic activity in saliva is useful as one of the periodontal disease activity tests. Furthermore, it might be imagined that this procedure is helpful for learning the progress and prognosis after operation for the periodontal diseases, which related with the systemic conditions, especially, with another organic anomalism.
- 有限責任中間法人 日本口腔衛生学会の論文