Impaired Mobilization of CD133+ Bone Marrow-Derived Circulating Progenitor Cells With an Increased Number of Diseased Coronary Arteries in Ischemic Heart Disease Patients With Diabetes
スポンサーリンク
概要
- 論文の詳細を見る
Background: The influence of the number of diseased coronary arteries on the mobilization of CD133/45+ bone marrow-derived circulating progenitor cells (BM-CPCs) in peripheral blood (PB) in patients with ischemic heart disease (IHD) was analyzed. Methods and Results: Mobilization of CD133/45+ BM-CPCs by flow cytometry was measured in 120 patients with coronary 1 vessel (IHD1, n=40), coronary 2 vessel (IHD2, n=40), and coronary 3 vessel disease (IHD3, n=40), and in a control group (n=40). The mobilization of CD133/45+ BM-CPCs was significantly reduced in patients with IHD compared to the control group (P<0.001). The mobilization of CD133/45+ BM-CPCs was impaired in patients with IHD3 compared to IHD1 (P<0.001) and to IHD2 (P<0.001). But there was no significant difference in mobilization of CD133/45+ BM-CPCs between the patients with IHD2 and IHD1 (P=0.35). Moreover, we found significantly reduced CD133/45+ cell mobilization in patients with a high SYNTAX-Score (SS) compared to a low SS (P<0.001) and an intermediate SS (P<0.001). In subgroup analyzes, we observed a significantly negative correlation between levels of hemoglobin A1c and the mobilization of CD133/45+ BM-CPCs (P=0.001, r=-0.6). Conclusions: The mobilization of CD133/45+ BM-CPCs in PB is impaired in patients with IHD. This impairment might augment with increased number of diseased coronary arteries. Moreover, mobilization of CD133/45+ BM-CPCs in ischemic tissue is further impaired by diabetes in patients with IHD. (Circ J 2011; 75: 2635-2641)
論文 | ランダム
- II-A-20 肝アルカリフォスファターゼの局在に関する酵素組織化学及び免疫組織化学的研究
- 68 喘息児童の登山訓練 : 低山トレーニングにおける呼吸機能への影響
- 大空間構造におけるアクチュエータ及びその他の周辺装置の最適配置問題, Eric Ponslet, Raphael T.Haftka and Harley H.Cudney : OPTIMAL PLACEMENT OF ACTUATORS AND OTHER PERIPHERALS FOR LARGE SPACE STRUCTURES[Proc. NATO Advanced Research Workshop on Topology Design of Structures, 1993, pp.135-14
- 1384 フェノールFRP外壁工法の開発 : (その2)フェノールFRPの遮音性能及び耐候性(部位別材料屋根・外壁,材料施工)
- 宇宙工学分野のインフレート構造, A. Beukers and others, INFLATABLE STRUCTURES IN SPACE ENGINEERING, [Journal of the international association for shell and spatial structures vol.41, 2000, pp.177-190](構造,文献抄録)