Pregnancy-Associated Aortic Dilatation or Dissection in Japanese Women With Marfan Syndrome
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概要
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Background: Aortic dilatation and dissection are severe complications of pregnancy that may cause maternal death. The purpose of the present study was to investigate risk factors for aortic dilatation or dissection in pregnant Japanese women with Marfan syndrome. Methods and Results: A total of 28 patients with Marfan syndrome were investigated retrospectively during pregnancy and after delivery at 1 institution. These patients were divided into 2 groups: those who experienced aortic dilatation or dissection (group D, n=11) and those who did not (group ND, n=17). In group D, aortic dilatation or dissection occurred in 7 cases during pregnancy (2 in the 2nd trimester, 5 in the 3rd trimester) and 4 cases after birth. The 2 cases in the 2nd trimester involved aortic dilatation >60mm and those patients underwent hemiarch replacement and a David operation, respectively. Delivery by cesarean section (64% vs. 18%, P<0.05), sinus of Valsalva ≥40mm (86% vs. 21%, P<0.05), aortic size index (size of sinus of Valsalva/body surface area) ≥25mm/m2 (7/7, 100% vs. 0/14, 0%, P<0.0001), and faster growth of the sinus of the Valsalva (median, [interquartile range]: 0.41mm/month [0.23-0.66mm/month] vs. 0.05mm/month [-0.13 to 0.22mm/month]; P<0.05) were significantly higher in group D than in group ND. Conclusions: A large sinus of Valsalva, increased aortic size index, and rapid growth of the sinus of Valsalva are risk factors for aortic dilatation or dissection in pregnant Japanese women with Marfan syndrome. (Circ J 2011; 75: 2545-2551)
論文 | ランダム
- 酵母細胞内での細菌由来β-ラクタマーゼ生成における増殖温度の効果
- 判別分析による水溶性化合物の引火性の分類
- 酵母YEpベクターにコードされる細菌由来β-ラクタマーゼの増殖に伴う活性の変化について
- 主成分分析法による有機化合物の引火点と化学構造との相関
- 「箱根」と外国人(第2部)