ペルフルブタン超音波イメージングによる血流解析の基礎検討

概要

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Linearity between signal intensity and concentration of the contrast medium enables to acquire quantitative hemodynamic information of the tissue. The aim of our study was to assess the relationship between contrast signal intensity(CI)of ultrasonography(US)and concentration of a perflubutane contrast-agent. Concentrations of the perflubutane solutions in spherically-shaped US phantom filled with pure water were varied with 0, 1.91, 3.81, 7.63, 30.52, 488.28, 1953.13, 7812.5×10-6L/L. Phantom images in each solution were obtained using multi-frequency linear probes with low mechanical-index(MI), i.e., MI of 0.2 at 3.5 and MI of 0.6 at 10 MHz. Then we evaluated the linearity between CIs and the concentrations with double logarithm scale, and time variability of the CI during the scan in each concentration. CIs in dB at each frequency had strong linear correlations with concentration in dB within the actual concentration range of the agent in human body. The CIs were temporally stable during the scan with each condition. The linear and temporally-stable characteristics under above mentioned conditions make it possible to obtain more detailed and quantitative hemodynamic analysis of the tissue.