Roles of Prostaglandin E2 in Cardiovascular Diseases : Focus on the Potential Use of a Novel Selective EP4 Receptor Agonist
スポンサーリンク
概要
- 論文の詳細を見る
Prostaglandin E2 (PGE2) is produced in inflammatory responses and regulates a variety of immunological reactions through 4 different receptor subtypes; EP1, 2, 3 and 4. However, the precise role of each receptor in cardiovascular disease has not yet been elucidated. Enhanced expression of some EPs has been observed in clinical and experimental cardiovascular diseases. EP agonists have been developed to clarify the role of each receptor. Recently, we developed a novel selective agonist to examine the effects of EP4 on cardiac transplantation, myocardial ischemia, and myocarditis. Of note, a selective EP4 agonist attenuated inflammatory cytokines and chemokines via attenuation of macrophage activation in inflammatory heart diseases. In this review article, we discuss the effects of PGE2 receptor agonists on the development of cardiovascular diseases.
論文 | ランダム
- 差別をとらえる新たな視点を (新たな解放理論の創造にむけて) -- (差別実態論)
- 脳幹梗塞によるdiaschisis
- 胆道癌におけるc-erbB-2(HER2/neu)の発現およびKi-67 labeling index(Ki-67LI)の臨床病理学的意義
- 盲腸原発MALTリンパ腫の1例
- OP-2-038 5-FU代謝関連酵素TS,DPDおよびPyNPaseの浸潤性膵管癌に対する術後化学療法の効果への影響