External genitalia Bowen cancers complicated by cervical cancer.

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A case of Bowen carcinoma on the vulva was described. The patient was 39 years old female and had a history of cervical carcinoma at the age of 35. She noticed a cutaneous lesion on her vulva about one year ago. It was growing slowly and became hemorrhagic. On examination, a 45×40mm sized erythematous lesion with greish white margin was found on the left side of her vulva. There were two granulomatous nodules, sized 13mm in diameter and bright red in color, in the lesion. Some blackish pigmented spots were distributed on the margin. A biopsy specimen was histolpgically diagnosed as a Bowen disease showing anaplastic epidermal cells containing multinucleated cells and dyskeratotic cells. Intradermal invasion of the same tumor cells was observed at the site of the nodules. Then the lesion was diagnosed as a Bowen carcinoma (squamous cell carcinoma (SCC), grade III, T3N0M0) . The tumor was removed with 10mm excision distance.Immunohistochemical stain using anti human papilloma virus (HPV) antibody was negative in the tumor cells of the Bowen carcinoma. Further, in situ hybridization using HPV type 6/11 and type 16 DNA probes was negative in both the Bowen carcinoma and the cervical carcinoma.There were 4 Bowen carcinomas and 13 Bowen diseases at our division in the years of 1983-1992. Therefore, 24% (4/17) of Bowen diseases became invasive Bowen carcinomas. On the other hand, out of 29 SCCs operated at our division for these 10 years, 5 SCCs deveroped on scar lesions, 4 developed on Bowen diseases and 3 deveroped in a patient with xeroderma pigmentosum variant.
日本皮膚悪性腫瘍学会の論文

External genitalia Bowen cancers complicated by cervical cancer.

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