Epithelioid sarcoma recurring in wide extirpation after 9 years and recognizing the reconstitution of N-ras genes.

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A 43-year-old-woman developed an elastic, hard node (2cm in diameter) on the anterior side of the right leg. The lesion was left untreated, until an ulcer had formed in its center. Simple resection was performed several times. However, the lesion recurred repeatedly. Based on a histopathological diagnosis of epithelioid sarcoma, the woman underwent amputation of the right leg 9 years ago. For 9 years after surgery, no recurrence was observed. The patient recently developed multiple painful ulcerative nodes (about 1cm in diameter) on the head, trunk and extremities. Because the patient refused extensive resection for religious reasons, local OK-432 therapy and high-dose cepharanthin therapy have been performed. Node formation is still continuing. Chromosomal analysis of removed tissue revealed various aberrations and N-ras oncogene rearrangement was detected.
日本皮膚悪性腫瘍学会の論文