A case of skin metastasis of malignant schwannoma.

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We report the case of a 79-year-old Japanese woman without von Recklinghausen's disease who had abdominal skin metastasis derived from a malignant schwannoma in the subcutaneus tissue near her rectum. Three years and 8 months after surgical removal of the subcutaneus tumor near the rectum, metastasis to the both lungs and the liver was recognized. After 6 months of chemotherapy (CYVADIC method), skin metastasis was observed. The skin tumor was removed, and the tumor cells were histochemically positive for S-100 and NSE, but vimentin-negative.Most malignant schwannomas reported by dermatologists are derived from neurofibromas of patients suffering from von Recklinghausen's disease. Most malignant schwannomas in the absence of von Recklinghausen's disease arise from the trigeminal nerve and stomach. Therefore, malignant schwannoma in the subcutaneus tissue near the rectum, as in this patient, is very rare. This is the first reported case of skin metastasis of malignant schwannoma.
日本皮膚悪性腫瘍学会の論文