Basosquamous cell carcinoma-免疫組織化学的所見および細胞増殖能による検討-

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A 80-year-old woman with basosquamous cell carcinoma is reported. The lesion began as a black flat nodule on the left side of the arm near the elbow 10 years ago. The lesion gradually enlarged to the size of 26×20mm, forming like a rosary at first examination. Histopathological findings showed that the tumor was composed of three different figures; Firstly, the solid BCE-like lesion that the tumor was consisted of basaloid cells with uniform oval basophilic nuclei and relatively little cytoplasm. The peripheral cell layer showed a palisade arrangement. Secondary, the intermedi-ate type lesion that the tumor showed the rough retiform construction, which was made up mainly of basaloid cells and showed transition to squamoid cells. Thirdly, SCC-like lesion that was composed of squamoid cells with relatively large nuclei and abundant cytoplasm. Many whorls of keratinocytes like squamous eddies were seen in this lesion. Immunohistochemically, the cells of intermediate type lesion and SCC-like lesion were positive for MA903, a monoclonal antibodyagainst cytokeratin. In contrast, MA904 showed a positive staining in the cells of individual cell keratiniza-tion and focal areas like squamous eddies. Cell proliferating activities using cytofluor-ometry. Argyrophilic Nucleolar Organizer Regions (AgNORs) and immunostaining using MIB-1 were also examined. Each three different lesions showed cytofluor-ometric histograms exhed diploid pattern (normal nuclear DNA content), high positive rates of AgNORs and %MIB-1.
日本皮膚悪性腫瘍学会の論文

Basosquamous cell carcinoma-免疫組織化学的所見および細胞増殖能による検討-

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