実験的閉塞性黄疸の肝内血管変化に関する研究

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Intra-hepatic vascular changes following ligatation of the common bile duct in the male rats, were studied at the 1, 2, 5 and 10th week periods after the operations.Histologically, the parenchymal cell degeneration in the centrolobular areas was observed on the 2nd day after the operations and proliferation of the intralobular bile ductules was seen in the periolobular areas at the 2nd week after the operations. Proliferated bile ductules in the portal triads were accompanied with proliferation of connective tissues and tended to surround the lobules at the 5th week. In a few cases of the 10th week group, histological features compatible with biliary cirrhosis were observed. Proliferation of connective tissues began mainly in the portal areas and partly in the central areas.Recognizable alteration of the intra-hepatic vessels was not observed at the 1st week period. At the 2nd week period, the terminal branches of the portal veins showed slight proliferation and distortion. After the 5th week of the experiments, the livers revealed marked dilatation and tortuosity of the large hepatic arteries, and distinct proliferation of the tortuous small or middle arteries. In some arteries of middle size, abrupt obliteration in a segmental fashion was observed. Prominent distortion and proliferation were seen in the portal veins of small to middle size, and porto-portal anastomoses were found in the vessels of middle size. On the other hand, the hepatic vein showed no recognizable alteration, except slight distortion in a few cases which showed pre-cirrhotic features.It was suggested that these vascular changes may be due to compression of vessels by the proliferated and dilated bile ductules. The intra-hepatic vascular alterations in obstructive jaundice were completely different from the features in liver injury induced by choline deficiency or CCl4 administration.

実験的閉塞性黄疸の肝内血管変化に関する研究

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