The experimental study on the gastro-duodeual ulcer:the developing process of the linear ulcer
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概要
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The linear type of ulcer has been reported to be observed in the chronic course of the gastric ulcer.This study was made on the developing process of the linear ulcer of the dog with the administration of "Cinchophen" comparing two groups; one of which was given a single course and the other was given several courses of the administration of it. Additionally, the various types of the deformation of the ulcer in the healing stage was also observed.1) Fifty adult dogs weighing 5 to 15kg were used. "Cinchophen" was administered to the dogs per os, in doses of 1-2gm. daily during 16.2 days on the average. The mean total dosage amounted to 16.6gm.The ulcer was found in 45 among 50 cases by necropsy.2) Gastroscopic examination was often performed in 5 of 50 cases during the first course of the administration of "Cinchophen". In 2 of the 5 cases, the multiple longitudinally-lined-up erosions with hemorrhage were found and some of them developed to the linear ulcers.From this observation, the intensified tension of the stomach wall caused by high inner pressure due to the repeated vomitting was considered to be the most important factor inducing these lesions as rarely observed in the clinical field. This view would be supported by the similarity of genesis of Mallory-Weiss Syndrome.3) The form of the ulcers produced by the first course of the administration of "Cinchophen" was mostly round or oval.The linear ulcer was found in 9 of 50 cases (18%), and in 5 of 9 cases the lesion was located in parallel with the stomach axis. In 2 cases, the linear ulcer was combined with the round ulcer.4) Eighteen adult dogs weighing 5 to 14kg were provided for the study of the healing stage of the ulcer.The ulcer became smaller centripetally in most of the cases, while it contracted partly eccentrically in few cases.5) Forty six adult dogs weighing 6 to 15kg were given several courses of "Cinchophen" administration. In this period, the healing and the aggravation were alternately observed especially by per-pertoneal endoscopy.The linear ulcers and the prodronal stage of linear ulcers were found in 21 of 46 cases. The ulcer often recurred adjacent to the preceding ulcer and the combination of the round ulcer and the linear one was also often observed. And these lesions experimentally thus produced were located at the border section between two areas with the different type of glands and were lined-up in the cross direction against the lesser curvature axis as usually observed in the clinical field.It is concluded that the various processes should be considered in the linear ulcer formation. For example, some of the ulcers located across the lesser curvature started in the linear type and some others changed their form from round to linear during the chronic course of the ulcer.The local factors would much influenced to the development and the deformation of the ulcers.
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