Experimental Studies on the Intestinal Absooption of Fat as Micellar Solution:with special reference to the behavior of monoglyceride
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概要
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Intestinal absorption of fat was studied experimentally with rats in both intragastric and intraduodenal administration in vivo and in vitro. Both administration of triolein, α-monoolein or oleic acid as oil, and the administration of mixed micellar solution containing oleic acid, α-monoolein and sodium taurocholate were performed. 131I-triolein, 131I-oleic acid and 125I-α-monoolein were used as tracers. Following results were obtained.1) Gastric emptying played important role in digestion and absorption of fat. Upon the receptor controlling gastric emptying sited in duodenal mucosa, fatty acid had more stimulatory effect (inhibitory effect) upon gastric emptying than triglyceride.2) Apparent absorption ratio based on total administered dose should be corrected by gastric emptying ratio.3) The mechanism of uptake of micellar solution was considered as simple diffusion. Fatty acid and monoglyceride were released from micelles at the epthelial surface and each lipid was taken up by simple diffusion, not by unit uptake. Fatty acid was taken up more rapidly than monoglyceride from micellar solution.4) Intact uptake of monoglyceride from micellar solution and subsequent biosynthesis of triglyceride via monoglyceride pathway in the intestinal mucosa was proved in vivo and in vitro.5) The possible existence of the enzyme which hydrolized monoglyceride specifically was proved in the intestinal mucosa.
- 財団法人 日本消化器病学会の論文