Studies on the splenic circulation in portal hypertension using trapezoidal-wave electromagnetic flowmeter
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There are many unsolved problems on the pathogenesis of splenomegaly in portal hypertension. A hemodynamic study on the spleen was carried out in experimental and clinical portal hypertension using trapezoidal-wave electromagnetic flowmeter of our own device.1. In 8 control dogs, splenic arterial flow (SAF) was 193.8±49.4ml/min (mean± S.E.) and a significant correlation was observed between SAF and spleen weight (SW) (r=0.97, p<0.001). The SAF/SW averaged 1.82±0.283ml/min/gm.2. In 5 dogs with presinusoidal obstruction induced by Amberlite particles, SAF indicated a significant increase and splenic enlargement was observed. The correlation coefficient between SAF and spleen length was r=0.93 (p<0.001). On the contrary, there was neither SAF increase nor splenic enlargement in 3 dogs with postsinusoidal obstruction by hepatic vein constriction, while portal venous flow (PVF) was significantly increased due to increase in mesenteric venous flow.3. Clinically, SAF was measured in 13 patients with portal hypertension (prehepatic obstruction 2 presinusoidal obstruction 6, postsinusoidal obstruction 5 and 3 controls). A significant degree of correlation was found between SAF and SW (r=0.90, p<0.001) regardless of the type of portal hypertension, and the mean SAF/SW was 0.415±0.040ml/min/gm.4. There was a fair degree of correlation between the calibre of splenic artery and SW as well, as measured on celiac arteriograms in 15 patients. The ratio of the calibres of splenic and portal veins was found to be related to the degree of portosystemic collateral development on portograms.These observations support that the determinant of the splenic arterial flow (SAF) is the degree of the splenomegaly.
- 財団法人 日本消化器病学会の論文
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関連論文
- 第6回日本肝臓学会総会 シンポジウム(V)
- Studies on the splenic circulation in portal hypertension using trapezoidal-wave electromagnetic flowmeter