薬剤性大腸炎の臨床的検討

概要

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A clinical study on 70 nonpseudomembranous cases of drug associated colitis was conducted after classifying them into the following 4 types according to the endoscopic findings. Type I (diffuse lesion) showed the highest incidence, seen in 40 cases. The features were; predilection for young people, high occurrence of bloody diarrhea and abdominal pain, high frequency of common cold as underlying disease, and many of the cases were given single administration of synthetized penicillins orally. Type II (longitudinal ulcer) seen in 7 cases was similar to Type I, except that a considerable number of the cases were administered cefems. Type III (aphthoid lesion) seen in 15 cases was similar to pseudomembranous colitis in many respects, such as the age of patients, symptoms, type of antibiotics, route of their administration, predilection place, and existence of C. difficile D1 toxin-positive case. Type IV (nonspecific lesion) seen in 8 cases was considered as the mild case of Type I or II according to the endoscopic examination, however, clinically there was no similarity. As mentioned above, the respective different onset mechanisms of Type I, II, III and IV were indicated.
財団法人日本消化器病学会の論文