Fasting serum squalene in patients with gallstones and hyperlipidemia.
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概要
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Fasting serum squalene (FSS) level was determined in patients with gallstones and hyperlipidemia. FSS and the lithogenic index of some gallstone patients were also determined before and during CDCA or UDCA administration. It was then discussed whether the measurement of FSS well reflects the synthesis rate of cholesterol in human subjects. Significant elevation of FSS was found in patients with cholesterol gallstone and type IV hyperlipidemia and this was accompanied by a high lithogenic index. The reason for the high incidence of gallstone in type IV may have been due to elevated synthesis of cholesterol and a situation of imminent gallstone formation is present in type IV. FSS was significantly decreased during CDCA administration, suggesting that CDCA inhibits cholesterol synthesis. FSS, which was high before medication, was also decreased during UDCA, although there was no statistically significant difference.It was concluded from the above results that the determination of FSS is clinically useful for the screening and treatment of gallstones and that FSS well reflects cholestrol synthesis in man.
- 財団法人 日本消化器病学会の論文