Experimental studies on pathogenesis of duodenal ulcer in cysteamine induced rats.

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概要

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• The mechanism of cysteamine induced ulcer formation has long been known to be due to increased acid output and pepsin activity. Howerver, the role of cysteamine in the pathogenesis of duodenal ulcer has remained unknown. The aim of this study was to periodically evaluate the changes of aggressive and defensive factors in cysteamine induced rats.We investigated the impairment of the local duodenal blood flow by means of the H+ clearance technique. Further, we have measured gastric acidity and pepsin activity. In addition, organ distribution of 35S-cysteamine detected with liquid scintillation counter and autoradiography was investigated. The duodenal ulcer incidence at 12 and 24 hours was higher than at 3 hours and duodenal mucosal blood flow decreased significantly 30 minutes after cysteamine administration. Gastric acidity and pepsin activity were increased 3 hours after administration. The activity of 35S-cysteamine in the duodenum was the highest at 1 hour and high level activity was maintained for 24 hours. 35S-cysteamine-labelled cells were located to the mucosal layer accompanied with dilatation of lymph vessels and infiltration of inflammatory cells at 30 minutes and 1 hour.I would like to emphasize the correlation between the change of duodenal microcirculation and ulcer formation on the basis of 35S-cysteamine accumlation in the duodenum. In conclusion, it is suggested that impairment of duodenal microcirculation may be due to direct destruction of the blood vessels or due to release of vasoactive amine from the tissue at a secondary step following cysteamine administration. Further, it may contribute to ulcer formation in rats.

• 財団法人 日本消化器病学会の論文

著者

• 池田 義毅

  杏林大学医学部第1外科

関連論文

• Cysteamine 投与による実験的十二指腸潰瘍の成因に関する研究 : 胃十二指腸粘膜攻撃, 防御因子の経時的解析 : 主論文の要旨
• Experimental studies on pathogenesis of duodenal ulcer in cysteamine induced rats.

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