Studies on the methods of diagnosing pancreatic cancer with the use of tumor markers by discriminant analysis.

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Although several tumor markers have been evaluated for the diagnosis of pancreatic cancer, there is no single marker that is adequate for diagnosis of pancreatic cancer. We have therefore attempted to differentiate cases of pancreatic cancer from chronic pancreatitis or normal subjects by the combined use of 13 kinds of pancreatic cancer markers determined in the same serum samples. A total of 100 samples were obtained from 50 patients with parcreatic cancer, 20 with chronic pancreatitis and 30 normal subjects. When only a single marker was employed, the best marker for the diagnosis of pancreatic cancer was CA19-9, while with combination assay the combination of CA19-9, TPA, ferritin and α1-AT, was found to be superior, but the diagnostic specificity of these markers was limited. Using discriminant analysis, CEA, α1-AT, ferritin and CA19-9 were weighted and the discriminant eqation y=-13.5+0.32ln (CEA)+0.32ln (ferritin)+1.83ln (α1-AT)+0.20ln (CA19-9) was derived. This equation was found to have 95% accuracy rate in distinguishing cases of pancreatic cancer from chronic pancreatitis or normal subjects. Furthermore, by adopting this equation in other patients with gastrointestinal cancers, we found it to have adequate organ specificity except for periampullary cancer. From this results, it may be concluded that the discriminant equation involving CEA, α1-AT, ferritin and CA19-9 is useful for the diagnosis of pancreatic cancer.
財団法人日本消化器病学会の論文

Studies on the methods of diagnosing pancreatic cancer with the use of tumor markers by discriminant analysis.

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